The morphostructure of an crest part of the Voronezh anteclise is closely related to the neotectonics of the territory. A feature of the newest structure, in contrast to the Paleozoic, Mesozoic and Paleogene structures, is predominantly the submeridional orientation of the interchanging raised and downdip blocks. The following regularities of the degree of the reflection of the deep inhomogeneities in neotectonic and geomorphological characteristics have been revealed. The zones of the reduced density at the top of the mantle have been noted to be corresponded in general by neotectonic blocks with the elevated relief. Areas of the high density values in a number of cases are corresponded by the Neogene-Quaternary blocks of the second rank with the reduced values of relief depth marks. Both of the relationships of the thickness of the earth’s crust and the height of the relief, negative and straight, have been observed. A complete spatial correlation between these parameters has been not observed, but on the whole, the structural plan of the Neogene-Quaternary structural-material complex is consistent with the spatial location of large heterogeneities in the litho sphere.